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Research

We perform mechanistic studies of enzymes at molecular and atomistic levels to improve our understanding of antibiotic resistance in bacteria and human cancers, in order to inform drug discovery and design.

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  • Deciphering enzyme specificity towards sulfated glycans

  • Rational design of enzymatic activities facilitated by structural and computational biology.

  • Activity-based inhibitor design and discovery

  • Mechanistic enzymology

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Our research is funded by

  • BBSRC Standard Grant (2022-2025), CoI

  • BBSRC Standard Grant (2023-2026), CoI

  • Chinese Scholarship Council Visiting Scholarship (2023), PI

  • Chinese Scholarship Council Studentships (2023-2027), PI

  • Manchester- Melbourne Dual Degree Studentship (2023-2027), PI

  • Manchester- Melbourne International Exchange award (2023), PI

  • Wellcome Trust Sir Henry Dale Fellowship (2021-2026), PI

  • University of Manchester Studentship (2021-2025), PI

  • Chinese Scholarship Council Studentships (2020-2024), PI

  • EPSRC Studentship (2019-2023), PI

  • The Royal Society Research Grant (2018-2019), PI

  • The Academy of Medical Sciences Springboard Award (2018-2020), PI

  • Wellcome Trust Seed Awards (2017-2019), PI

  • Cardiff University Studentship (2017-2021), PI

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