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We perform mechanistic studies of enzymes at molecular and atomistic levels to improve our understanding of antibiotic resistance in bacteria and human cancers, in order to inform drug discovery and design.

  • Deciphering enzyme specificity towards sulfated glycans

  • Rational design of enzymatic activities facilitated by structural and computational biology.

  • Activity-based inhibitor design and discovery

  • Mechanistic enzymology

Our research is funded by

  • BBSRC Standard Grant (2022-2025), CoI

  • BBSRC Standard Grant (2023-2026), CoI

  • Chinese Scholarship Council Visiting Scholarship (2023), PI

  • Chinese Scholarship Council Studentships (2023-2027), PI

  • Manchester- Melbourne Dual Degree Studentship (2023-2027), PI

  • Manchester- Melbourne International Exchange award (2023), PI

  • Wellcome Trust Sir Henry Dale Fellowship (2021-2026), PI

  • University of Manchester Studentship (2021-2025), PI

  • Chinese Scholarship Council Studentships (2020-2024), PI

  • EPSRC Studentship (2019-2023), PI

  • The Royal Society Research Grant (2018-2019), PI

  • The Academy of Medical Sciences Springboard Award (2018-2020), PI

  • Wellcome Trust Seed Awards (2017-2019), PI

  • Cardiff University Studentship (2017-2021), PI

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