Biography
Yi Jin （金轶）took her BSc degree in Chemistry in 2005 from Xiamen University, China. In 2008, she obtained her MSc degree in Organic Chemistry after completing her Master's thesis in the group of Prof. Yufen Zhao （赵玉芬）, Academician of CAS, at Xiamen University, working on the synthesis of transition state analogue inhibitors of phosphoserine phosphatase and phosphopeptides. In 2008, she was awarded the prestigious Overseas Research Studentship (ORS) by British Council and came to the UK for her PhD under the guidance of Prof. Jon P. Waltho and Prof. G. Mike Blackburn at the University of Sheffield, UK (see the "Holy Grail or Trojan Horse" story behind). During this period, she expanded the usage of metal fluoride complexes as mimics of phosphoryl group in various key enzymes in cellular signal transduction in NMR and crystallography. She stayed in the same lab as a postdoc for 2 years working on the strain catalysis of DNA repairing enzyme UNG using multi-dimensional NMR. In 2014, she moved to the group of Prof. Gideon J. Davies, FRS, FMedSci in YSBL, University of York, UK, working on various carbohydrate processing enzymes, including the first glycosyl hydrolases in sulfo-glycolytic pathways, the first mannosidase in GH134 family, and using activity based-probes to trap glucuronidases in action.
In May 2017, she was appointed as a University Research Fellow at Cardiff University to begin her independent research career. In August 2021, she was appointed as a Wellcome Trust Sir Henry Dale Fellow at Manchester Institute of Biotechnology, The University of Manchester.
Her research interests involve mechanistic studies and protein interactions of disease-relevant phosphoryl transfer enzymes and carbohydrate processing enzymes using bioinformatics, organic synthesis, chemical biology, molecular biology, NMR, and crystallographic approaches.
Presentations
2022 May European Symposium on Biological and Organic Chemistry, Gregynog, UK
2022 Feb Department of Chemistry, University of Warwick. Norfork, UK
2021 Nov Department of Chemistry, University of Bristol. Bristol, UK
2021 Oct Department of Chemical Biology, Xiamen University. Xiamen, China
2020 Nov Wilfrid Laurier University, webinar. Waterloo, Canada.
2020 Oct MRC Protein Phosphorylation and ubiquitylation Unit, webinar. Dundee, UK.
2020 Oct European Glycoscience Community webinar. RSC.
2020 Jan Dalian University of Technology. Dalian, China
2019 Dec International Symposium on Bioorganic Chemistry-12. Shenzhen, China.
2019 Sept Beijing Normal University. Beijing, China.
2019 Jun Max-Planck Developmental Biology. Tubingen, Germany.
2019 May Pharmaceutical Sciences, Cardiff University. Cardiff, UK.
2018 May European Symposium on Biological and Organic Chemistry. Gregynog, UK.
2018 Jan Global Scientist Forum. Shenzhen, China.
2017 Sept Xiamen-Cardiff Bilateral Workshop in Chemistry. Xiamen, China.
2017 Sept RSC Chemical Biology and Bioorganic Group Symposium. Firbush, UK.
2017 Jul South West Structure Biology Conference. Cardiff, UK.
2017 May Cardiff Chemistry Conference, Cardiff University. Cardiff, UK.
2017 Jan Department of Chemical Biology, Xiamen University. Xiamen, China.
2016 Dec Silk Road Young Scholar’s Forum. Xi’an, China.
2016 Oct International Conference on Phosphorus Chemistry. Kazan, Russia.
2014 Oct Krebs Institute Symposium. Sheffield, UK.
2010 Oct White Rose Protein Forum Meeting. Sheffield, UK.
2010 June Trends in Enzymology. Ascona, Switzerland.