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Peer Reviewed

Arginine Kinase Activates Arginine for Phosphorylation by Pyramidalization and Polarization

F. Falcion, R. W. Molt Jr., Y. Jin, J. P. Waltho, S. Hay*, N. G. J​ Richards*, G. Michael Blackburn*​ 

ACS Catal., 2024, DOI:10.1021/acscatal.4c00380

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Roles of Inter- and Intramolecular Tryptophan Interactions in Membrane-active Proteins Revealed by Racemic Protein Crystallography.

A.J. Lander, L.D. Mercado, X. Li, I.M. Taily, B.L. Findlay*, Y. Jin*, L.Y.P Luk*

Comm. Chem., 2023, 6, 154.

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Mechanistic and Structural Insights into the Specificity and Biological Functions of Bacterial Sulfoglycosidases.

Z. Zhang, M. Dong, R. Zallot, G.M. Blackburn, N. Wang, C. Wang, L. Chen, P. Baumann, Z. Wu, Z. Wang, H. Fan, C. Roth, Y. Jin*, Y. He*

ACS Catal. 2023, 13, 1, 824–836.

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The Role of Streptavidin and its Variants in Catalysis by Biotinylated Secondary Amines. 

A.R. Nödling, N. Santi, R. Castillo, M. Lipka-Lloyd, Y. Jin, L.C. Morrill, K. Świderek*, V. Moliner*, L.Y.P. Luk* 

Org. Biomol. Chem., 2021, 19, 10424.

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The Development of Non-Hydrolysable Oligosaccharide Activity-Based Inactivators for Endoglycanases: A Case Study on beta-1,6 Mannanases.

S.P. Schröder, W.A. Offen, A. Males, Y. Jin, C. Boer, J. Enotarpi, L. Marino, G.A. van der Marel, B.I. Florea, J.D.C. Codée,

H.S. Overkleeft*, G.J. Davies*   

Chem. Eur. J. 2021, 27, 9519-9523

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Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis.

M. Sharma, P. Abayakoon, R. Epa, Y. Jin, J. Lingford, T. Shimada, M. Nakano, A. Ishihama, J. Mui, E. Goddard-Borger*, G.J. Davies*, S.P. Williams* 

ACS Cent. Sci. 2021, 7, 476-487

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Octahedral Trifluoromagnesate, an Anomalous Metal Fluoride Species, Stabilizes the Transition State in a Biological Motor.

M. Ge, R.W. Molt Jr, H.T. Jenkins, G.M. Blackburn, Y. Jin*, A.A. Antson* 

ACS Catal. 2021, 11, 2769-2773

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Dynamic Structural Changes Accompany the Production of Dihydroxypropanesulfonate by Sulfolactaldehyde Reductase.

M. Sharma, P. Abayakoon, J. Lingford, R. Epa, A. John, Y. Jin, E. Goddard-Borger*, G. Davies*, S. Williams*

ACS Catal. 2020, 10, 2826-2836.

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An unexpected co-crystal structure of the calpain PEF(S) domain with Hfq reveals a potential chaperone function of Hfq.

J. Cresser-Brown, P. Rizkallah, Y. Jin, C. Roth, D.J. Miller, R.K. Allemann*  

Acta Cryst. F 2020, 76, F76, 81–85

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High-resolution Crystal Structure of Human Asparagine Synthetase Enables Analysis of Inhibitor Binding and Selectivity.

W. Zhu, A. Radadiya, C. Bisson, S. Wenzel, B.E. Nordin, F. Martínez-Márquez, T. Imasaki, S. Sedelnikova, A. Coricello, P. Baumann, A.H. Berry, T.K. Nomanbhoy, J. W. Kozarich, Y. Jin, D.W. Rice, Y. Takagi*, N.G.J Richards*

Comm. Biol. 2019, 2, 345.

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Crystal Structure and Biophysical Analysis of Furfural Detoxifying Aldehyde Reductase from Clostridium beijerinkii. 

A. Scott, J. Cresser-Brown, T. Williams, P. Rizkallah, Y. Jin, L.Y.P. Luk, R.K. Allemann*

Appl. Environ. Microbiol. 2019, 85, e00978-19. 

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Label‐Free Visualization of Carbapenemase Activity in Living Bacteria. 

Y. Zhang, J. Lei, Y. He*, J.H. Yang, W.J. Wang, A. Wasey, J.R. Xu*, Y. Lin, H.M. Fan, G.Y. Jing, C. Zhang, Y. Jin 

Angew. Chem. Int. Ed. 2018, 57, 17120–17124.

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Reactivity and Selectivity of Iminium Organocatalysis Improved by a Protein Host. 

A. R. Nödling, K. Swiderek, R. Castillo,  J. W. Hall,  A. Angelastro,  L.C. Morrill,  Y. Jin,  Y.H. Tsai,  V. Moliner*,  L.Y.P. Luk* 

Angew. Chem. Int. Ed. 2018, 57, 12478-12482.

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Thermokinetic Profile of NDM-1 and Its Inhibition by Small Carboxylic Acids. 

Q. Wang, Y. He*, R. Lu, W.M. Wang, K.W. Yang*, H.M. Fan, Y.  Jin, G.M. Blackburn

Biosci. Rep. 2018, DOI: 10.1042/BSR20180244.

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Publications arising from Postdoctoral and PhD work:

Structural and Biochemical Insights into the Function and Evolution of Sulfoquinovosidases.

P. Abayakoon, Y. Jin, J.P. Lingford, M. Petricevic, A. John, E. Ryan, J.W.Y. Mui, D.E.V. Pires, D.B. Ascher, G.J. Davies*, E.D. Goddard-Borger*, S.J. Williams*

ACS Cent. Sci. 2018, 4, 1266–1273.

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van der Waals Contact between Nucleophile and Transferring Phosphorus is Insufficient to Achieve Enzyme Transition State Architecture.

L.A. Johnson, A.J. Robertson, N.J. Baxter, C. Trevitt, C. Bisson, Y. Jin, H. Wood, A.M. Hounslow, M.J. Cliff, G.M. Blackburn, M.W. Bowler*, J.P. Waltho*  

ACS Catal. 2018, 8, 8140-8153.

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Discovery and characterization of a  sulfoquinovose mutarotase using kinetic analysis at equilibrium by exchange spectroscopy.

P. Abayakoon, J.P. Lingford, Y. Jin, C. Bengt, G.J. Davies, S.G. Yao*, E.D. Goddard-Borger*, S.J. Williams*

Biochem.  J. 2018, 475, 1371-1383.

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Assessing the Influence of Mutation on GTPase Transition States Using X-ray, 19F NMR, and DFT Approaches.

Y. Jin, R.W. Molt Jr., E. Pellegrini, M.J. Cliff, M.W. Bowler*, N.G.J. Richards*, G.M. Blackburn*, J.P. Waltho*

Angew. Chem. Int. Ed. 2017, 56, 9732-9735.

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Review: Metal Fluorides as Analogues for Studies on Phosphoryl Transfer Enzymes.

Y. Jin, N.G.J. Richards, G.M. Blackburn, J.P. Waltho

Angew. Chem. Int. Ed. 2017, 56, 4110-4228

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Review: Metal Fluorides: Tools for Structural and Computational Analysis of Phosphoryl Transfer Enzymes.

Y. Jin, R.W. Molt, Jr., G.M. Blackburn

Topics Curr. Chem. 2017, 375, 36.

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An Atypical Interaction Explains the High-affinity of a Non-hydrolyzable S-linked 1,6-Alpha-Mannanase Inhibitor. 

T. Belz, Y. Jin, J. Coines, C. Rovira*, G.J. Davies*, S.J. Williams*

Chem. Comm. 2017, 53, 9238-9241.

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Activity-based Probes for Functional Interrogation and Discovery of exo- and endo-Retaining Beta-glucuronidases.

L. Wu, J. Jiang, Y. Jin, W.W. Kallemeijn, C. Kuo, W. Dai, C. van Elk, M.C. van Eijk, G.A. van der Marel, J.D.C. Codée, B.I. Florea, J.M.F.G. Aerts, H.S. Overkleeft*, G.J. Davies*

Nat. Chem. Biol. 2017, 13, 867-873.

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A β-Mannanase with a Lysozyme-like Fold and a Novel Molecular Catalytic Mechanism. 

Y. Jin, M. Petricevic, A. John, L. Raich, H. Jenkins, L.P. De Souza, F. Cuskin, H.J. Gilbert, C. Rovira*, E.D. Goddard-Borger*, S.J. Williams*, G.J. Davies*

ACS Cent. Sci. 2016, 2, 896–903.

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19F NMR and DFT Analysis Reveal Structural and Electronic Transition State Features for RhoA-Catalyzed GTP Hydrolysis. 

Y. Jin, R.W. Molt, Jr., J.P. Waltho*, N.G.J. Richards*, G.M. Blackburn*  

Angew. Chem. Int. Ed. 2016, 55, 3318-3322.

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Chemoenzymatic Synthesis of 6-Phospho-Cyclophellitol as a Novel Probe of 6-Phospho-beta-glucosidases.

D.H. Kwan*, Y. Jin, J. Jiang, H. Chen, M. P. Kötzler, H. S. Overkleeft, G. Davies, S. G. Withers

FEBS Lett. 2016, 590, 461-468.

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YihQ is a Sulfoquinovosidase that Cleaves Sulfoquinovosyl Diacylglyceride Sulfolipids.

G. Speciale, Y. Jin, G.J. Davies*, S.J. Williams*E.D. Goddard-Borger*

Nat. Chem. Biol. 2016,12, 215–217.

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α-Fluorophosphonates Reveal How a Phosphomutase Conserves Transition State Conformation over Hexose Recognition in its Two-step Reaction.

Y. Jin, D. Bhattasali, E. Pellegrini, S.M. Forget, N.J. Baxter, M.J. Cliff, M.W. Bowler, D.L. Jakeman*, G.M. Blackburn*, J.P. Waltho*

Proc. Natl. Acad. Sci. USA 2014, 111, 12384-12389.

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Charge-balanced Metal Fluoride Complexes for Protein Kinase a with Adenosine Diphosphate and Substrate peptide SP20.

Y. Jin, M.J. Cliff, N.J. Baxter, H.R.W. Dannatt, A.M. Hounslow, M.W. Bowler, G.M. Blackburn*, J.P. Waltho*  

Angew. Chem. Int. Ed. 2012, 51, 12242-12245. Highlighted by Faculty of 1000 Prime.

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Review: Reflections on Biocatalysis Involving Phosphorus.

G.M. Blackburn, M.W. Bowler, Y. Jin, J.P. Waltho

Biochem. (Moscow), 2012, 77, 1083-1096.

Benzoylmethyl pyridine-4-carboxylate.

J.N. Guo*, B. Zhang, Y. Jin, G. Tang, Y.F. Zhao

Acta Cryst. E. 2008, E64(6), o1104/1-o1104/8.


Benzoyl­methyl 4-chloro­benzoate.

Y. Jin*, J.N. Guo, K. Lin, T. Ji, G. Tang  

Acta Cryst. E. 2008, E64(2), o507/1-o507/13.


(S)-N-(1-Benzyl-2-hydroxyethyl) benzamide.

Y. Cai*, H. Fang, Y. Jin, Q.L. Zeng and Y.F. Zhao

Acta Cryst. E. 2005, E61, o3912–o3913.

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