“The joy of discovery is certainly the liveliest that the mind of man can ever feel”

- Claude Bernard -

Publications
Publications arising from independent laboratory:

6.   W. Zhu, A. Radadiya, C. Bisson, S. Wenzel, B.E. Nordin, F. Martínez-Márquez, T. Imasaki, S. Sedelnikova, A. Coricello, P. Baumann, A.H. Berry, T.K. Nomanbhoy, J. W. Kozarich, Y. Jin, D.W. Rice, Y. Takagi, N.G.J Richards. High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivity. Comm. Biol. 2019, 2, 345.

5.   A. Scott, J. Cresser-Brown, T. Williams, P. Rizkallah, Y. Jin, L.Y.P. Luk, R.K. Allemann. Crystal Structure and Biophysical Analysis of Furfural Detoxifying Aldehyde Reductase from Clostridium beijerinkii. Appl. Environ. Microbiol. 2019, DOI: 10.1128/AEM.00978-19. 

4.   R. W. Molt Jr., E. Pellegrini, Y. Jin†. A GAP‐GTPase‐GDP‐Pi Intermediate Crystal Structure Analyzed by DFT Shows GTP Hydrolysis Involves Serial Proton Transfers.  Chem. Eur. J. 2019, DOI: 10.1002/chem.201901627.

 

3.   Y. Zhang, J. Lei, Y. He, J.H. Yang, W.J. Wang, A. Wasey, J.R. Xu, Y. Lin, H.M. Fan, G.Y. Jing, C. Zhang, Y. JinLabel‐Free Visualization of Carbapenemase Activity in Living Bacteria. Angew. Chem. Int. Ed.   2018, DOI:10.1002/anie.201810834.

 

2.    A. R. Nödling*, K. Swiderek, R. Castillo,  J. W. Hall,  A. Angelastro,  L.C. Morrill,  Y. Jin,  Y.H. Tsai,  V. Moliner,  L.Y.P. Luk. Reactivity and Selectivity of Iminium Organocatalysis Improved by a Protein Host. Angew. Chem. Int. Ed. 2018, 57, 12478-12482. 

 

1.    Q. Wang, Y. He, R. Lu, W.M. Wang, K.W. Yang, H.M. Fan, Y.  Jin, G.M. Blackburn. Thermokinetic Profile of NDM-1 and Its Inhibition by Small Carboxylic Acids. Biosci. Rep. 2018, DOI: 10.1042/BSR20180244.

 

Publications arising from Postdoctoral and PhD work:

18.   P. Abayakoon*, Y. Jin*, J.P. Lingford, M. Petricevic, A. John, E. Ryan, J.W.Y. Mui, D.E.V. Pires, D.B. Ascher, G.J. Davies, E.D. Goddard-Borger, S.  J. Williams. Structural and Biochemical Insights into the Function and Evolution of SulfoquinovosidasesACS Cent. Sci. 2018, 4, 1266–1273.

 

17.    L.A. Johnson, A. Robertson, N. J. Baxter, C. Trevitt, C. Bisson, Y. Jin, H. Wood, A. M. Hounslow, M. J. Cliff, G. M. Blackburn, M. W. Bowler, J.  P. Waltho. van der Waals contact between nucleophile and transferring phosphorus is insufficient to achieve enzyme transition state architecture. ACS Catal. 2018, 8, 8140-8153.

 

16.    P. Abayakoon*, J. P. Lingford, Y. Jin, C. Bengt, G. J. Davies, S. G. Yao, E. D. Goddard-Borger, S. J Williams, Discovery and characterization of a  sulfoquinovose mutarotase using kinetic analysis at equilibrium by exchange spectroscopy. Biochem.  J. 2018, 475, 1371-1383.

 

15.    Y. Jin*, R. W. Molt Jr.*, E. Pellegrini*, M. J. Cliff, M. W. Bowler, N. G. J. Richards, G. M. Blackburn, J. P. Waltho. Assessing the influence of mutation on GTPase transition states using X-ray, 19F NMR, and DFT approaches. Angew. Chem. Int. Ed. 2017, 56, 1-5.

 

14.    Y. Jin*, R. W. Molt, Jr.*, G. M. Blackburn. Metal Fluorides: Tools for structural and computational analysis of phosphoryl transfer enzymes. Topics Curr. Chem. 2017, 375, 36.

 

13.    T. Belz*, Y. Jin, J. Coines, C. Rovira, G.J. Davies, S. J. Williams. An atypical interaction explains the high-affinity of a non-hydrolyzable S-linked 1,6-alpha-mannanase inhibitor. Chem. Comm. 2017, 53, 9238-9241.

 

12.    L. Wu*, J. Jiang*, Y. Jin*, W. W. Kallemeijn, C. Kuo, W. Dai, C. van Elk, M. C. van Eijk, G. A. van der Marel, J. D. C. Codée, B. I. Florea, J. M. F. G. Aerts, H. S. Overkleeft, G. J. Davies. Activity-based probes for functional interrogation and discovery of exo- and endo-retaining beta-glucuronidases. Nat. Chem. Biol. 2017, 13, 867-873.

 

11.    Y. Jin*, J. P. Waltho, N. G. J. Richards, G. M. Blackburn. Metal Fluorides as analogs for studies on phosphoryl transfer enzymes. Angew. Chem. Int. Ed. 2017, 56, 4110-4128.

 

10.    Y. Jin*, M. Petricevic, A. John, L. Raich, H. Jenkins, L. P. De Souza, F. Cuskin, H. J. Gilbert, C. Rovira, E. D. Goddard-Borger, S. J. Williams, G. J. Davies. A β-Mannanase with a lysozyme-like fold and a novel molecular catalytic mechanism. ACS Cent. Sci. 2016, 2, 896–903.

 

9.    Y. Jin*, R. W. Molt, Jr.*, J. P. Waltho, N. G. J. Richards, G. M. Blackburn.  19F NMR and DFT Analysis reveal structural and electronic transition state features for RhoA-catalyzed GTP hydrolysis. Angew. Chem. Int. Ed. 2016, 55, 3318-3322.

 

8.    D. H. Kwan*, Y. Jin, J. Jiang, H. Chen, M. P. Kötzler, H. S. Overkleeft, G. Davies, S. G. Withers. Chemoenzymatic synthesis of 6-phospho-cyclophellitol as a novel probe of 6-phospho-beta-glucosidases. FEBS Lett. 2016, 590, 461-468.

 

7.    G. Speciale*, Y. Jin*, G. J. Davies, S. J. Williams, and E. D. Goddard-Borger. YihQ is a sulfoquinovosidase that cleaves sulfoquinovosyl diacylglyceride sulfolipids. Nat. Chem. Biol. 2016,12, 215–217.

 

6.    Y. Jin*, D. Bhattasali*, E. Pellegrini*, S. M. Forget, N. J. Baxter, M. J. Cliff, M. W. Bowler, D. L. Jakeman, G. M. Blackburn, J. P. Waltho. α-Fluorophosphonates reveal how a phosphomutase conserves transition state conformation over hexose recognition in its two-step reaction. Proc. Natl. Acad. Sci. USA 2014, 111, 12384-12389.

 

5.    Y. Jin*, M. J. Cliff, N. J. Baxter, H. R. W. Dannatt, A. M. Hounslow, M. W. Bowler, G. M. Blackburn, J. P. Waltho. Charge-balanced metal fluoride complexes for protein kinase A with adenosine diphosphate and substrate peptide SP20. Angew. Chem. Int. Ed. 2012, 51, 12242-12245. Highlighted by Faculty of 1000 Prime.

 

4.    G. M. Blackburn, M. W. Bowler, Y. Jin, J. P. Waltho. Reflections on biocatalysis involving phosphorus. Biochem. (Moscow), 2012, 77, 1083-1096.

 

3.    J. Guo*, B. Zhang, Y. Jin, G. Tang, Y. Zhao. Benzoylmethyl pyridine-4-carboxylate. Acta Cryst. E. 2008, E64(6), o1104/1-o1104/8.

 

2.    Y. Jin*, J. Guo, K. Lin, T. Ji, G. Tang.  Benzoyl­methyl 4-chloro­benzoate. Acta Cryst. E. 2008, E64(2), o507/1-o507/13.

 

1.    Y. Cai*, H. Fang, Y. Jin, Q. Zeng and Y. Zhao. (S)-N-(1-Benzyl-2-hydroxyethyl) benzamide. Acta Cryst. E. 2005, E61, o3912–o3913.

Cardiff University

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© 2017 by Yi Jin.